[青年邀请报告]共组装双螺旋框架结构实现手性对映体的反向光学响应
共组装双螺旋框架结构实现手性对映体的反向光学响应
编号:25 访问权限:仅限参会人 更新:2026-09-29 11:13:26 浏览:14次 青年邀请报告

报告开始:2026年10月14日 09:45 (Asia/Shanghai)

报告时间:15min

所在会议:[S2] 10月14日上午分会场 » [S2-5] 分会场五

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摘要
手性对映体的差异化物理和化学响应是理解生命体手性作用机制及开发高纯手性生物医药的重要前提。受限于单一结合位点和作用机制,手性对映体往往呈现出同向物化响应(仅微小强度差异)。与之不同,自然界如生命体系通过多级手性结构和结合位点,能够对手性对映体实现不同甚至截然反向的生物应答。通过模拟酶由多级肽链共组装而成的动态手性结构,我们设计和开发出基于动态氢键共组装的双螺旋框架结构,并实现了至少三十余种手性对映体的反向光学响应:手性依赖的荧光聚集增强(AIE)和聚集猝灭(ACQ)。纳瓦等温滴定量热仪表明反向响应过程分别对应螺旋有序(AIE,DH<0且DS<0)和螺旋无序(ACQ,DH>0且DS>0)的不同热力学机制,且从分子作用层面得到了实验和模拟结果的一致验证。我们还进一步开发了针对手性对映体ee值的高通量快速微孔读板技术,突破了同向响应识别线性差、精确度低及无法直接测定R,S构型的瓶颈。相比于HPLC金标准,本技术在市售手性医药和中间体的ee测定中,具备灵敏度高、绝对误差<1% ee、检测超快速(~1秒/样品)和近零溶剂耗量的显著优势。
关键字
手性;组装;光学;动态框架
报告人
郭俊
天津工业大学

Jun Guo obtained his B.S. from Huazhong University of Science and Technology, received his Ph.D. in Physical Chemistry at Peking University/National Center for Nanoscience and Technology (supervised by Prof. Zhiyong Tang and Prof. Hailin Peng), and conducted postdoctoral research at City University of Hong Kong (collaborating with Prof. Hua Zhang). He was recruited by Tiangong University in 2021 and currently serves as a full Professor. He was awarded the Tianjin Overseas High-Level Young Talent and Tianjin Higher Education Young Faculty Research Innovation Grant (U40 Cultivation). Focusing on design, construction, and applications of chiral structures/materials, he has published >100 papers (cited >7,000 times, H-index=38), including first/corresponding authorships in Chem. Soc. Rev. (1), J. Am. Chem. Soc. (3), Angew. Chem. Int. Ed. (2), Nat. Commun. (2), Natl. Sci. Rev. (1), Sci. Adv. (1), Adv. Mater. (1), Chem (2), and Matter (3). He received Outstanding Editorial Board Member awards from Nano Research and SmartMat, and was also named "Emerging Investigator" by J. Mater. Chem. A. and Nanoscale.

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